Overview
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In plain language
SHLP2 (small humanin-like peptide 2) is a natural peptide of 26 amino acids. Like humanin, its genetic instructions are found in mitochondria, the energy factories inside cells.
It was described in 2016. In cell and animal studies, it supported mitochondrial health, improved insulin sensitivity and helped cells survive stress. It has not been tested as a treatment in people and is not FDA-approved.
For students
SHLP2 is one of six small humanin-like peptides (SHLP1–6) identified by Cobb and colleagues in Pinchas Cohen's lab in 2016. All are encoded by short open reading frames within the mitochondrial 16S rRNA gene (MT-RNR2), the same region that encodes humanin.
In cells, SHLP2 increased oxygen consumption and ATP production and reduced apoptosis. In rats, it increased insulin sensitivity. Circulating levels have been reported to decline with age.
For researchers and instructors
Human data. Observational studies have associated SHLP2 levels with age and, in one study, prostate cancer risk. No interventional trials.
Methodology. Tissue expression and plasma levels depend on antibody assays that need further validation.
Status. Not FDA-approved; graded Preclinical.
Molecular identity
- Amino acids
- 26
- Molecular weight
- ~3,017.5 Da
- Formula
- C₁₄₂H₂₁₄N₃₆O₃₅S
- Sequence
- MGVKFFTLSTRFFPSVQRAVPLWTNS
Sequence map
Hydropathy
Kyte–Doolittle score per residue. Positive values are water-repelling.
Origin and history
In 2016 Laura Cobb, Pinchas Cohen and colleagues searched mitochondrial DNA by computer for more humanin-like genes. They found six, naming them small humanin-like peptides 1 to 6 (SHLP1–6).
SHLP2 stood out for protecting cells and improving metabolism in lab studies, and its blood levels decline with age. Research is still at an early stage.
Key people
- Laura Cobb & Pinchas CohenUSC
Timeline
- 2001
Humanin discovered
- 2016
SHLP1–6 described
See every peptide on one history timeline.
Human evidence
Human data are limited to observational measurements.
Registration and enrollment are not proof of benefit; check study results directly.
Explore original publications and distinguish preclinical findings from controlled human evidence.
Safety and regulatory status
See every compound on the regulatory tracker.
Not FDA-approved.
This profile is educational and does not provide treatment, dosing or sourcing guidance.
Sources
- PubMed literature search: SHLP2
- PubChem compound search: SHLP2
- Cobb et al. 2016, Aging
- ClinicalTrials.gov search: SHLP2
Hernandez Gener, E. (2026, November 7). SHLP2: molecular data, research history and evidence. VALREXA Biosciences. https://valrexa.com/peptides/shlp2.html
APA style · Last reviewed November 7, 2026 · Our editorial standardsLast reviewed November 7, 2026. Trial and regulatory status can change; confirm in the linked registries. This profile is educational and is not medical advice, a treatment recommendation, or dosing or sourcing guidance. Report an error · Corrections policy